Oral lysine clonixinate in the acute treatment of migraine: a double-blind placebo-controlled study
Arq. neuropsiquiatr
; 59(1): 46-49, Mar. 2001. graf
Article
en En
| LILACS
| ID: lil-284236
Biblioteca responsable:
BR1.1
RESUMO
Several oral nonsteroidal anti-inflammatory drugs (NSAIDs) are effective to treat migraine attacks. Lysine clonixinate (LC) is a NSAID derived from nicotinic acid that has proven to be effective in various pain syndromes such as renal colic and muscular pain. The aim of this double-blind, placebo-controlled study was to evaluate the efficacy of oral LC compared to placebo in the acute treatment of migraine. Sixty four patients with the diagnosis of migraine, according to the IHS criteria, were studied prospectively. Patients received LC or placebo once the headache reached moderate or severe intensity for 6 consecutive attacks. With regard to the moderate attacks, LC was superior than placebo after 1, 2 and 4 hours. The consumption of other rescue medications after 4 hours was significantly higher in the placebo group. With regard to the severe attacks, there was no difference between the active drug group and the placebo group concerning headache intensity and consumption of other rescue medications. We conclude that the NSAID lysine clonixinate is effective in treating moderately severe migraine attacks. It is not superior than placebo in treating severe migraine attacks
Texto completo:
1
Índice:
LILACS
Asunto principal:
Analgésicos
/
Lisina
/
Trastornos Migrañosos
Tipo de estudio:
Clinical_trials
/
Observational_studies
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Arq. neuropsiquiatr
Asunto de la revista:
NEUROLOGIA
/
PSIQUIATRIA
Año:
2001
Tipo del documento:
Article