Paragangliomas of the head and neck: clinical, morphological and immunohistochemical aspects
São Paulo med. j
;
119(3): 114-118, May 2001. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-285537
ABSTRACT
CONTEXT Protein marker positivity can assist in the definition of the therapeutic approach towards head and neck paragangliomas. The establishment of the therapeutic approach should incorporate the results of such an investigation. OBJECTIVE:
To establish criteria for benignancy and malignancy of vagal and jugular-tympanic paragangliomas, via the study of the relationships of sex, age, tumor size, duration of complaints, site, family history, presence of metastases, treatment, histological architecture and cell type with the immunohistochemical reactions to S100 protein, chromogranin and AgKi67.DESIGN:
A retrospective study of histological and clinical records.SETTING:
The Heliópolis and Oswaldo Cruz tertiary general hospitals, Säo Paulo. SAMPLE 8 cases of head and neck paragangliomas. MAIN MEASUREMENTS Determination of degree of positivity to paragangliomas via immunohistochemical reactions.RESULTS:
1). The protein markers for the principal cells (AgKi67 and chromogranin) were sensitive in 100 percent of the tumors when used together. 2). S100 protein was well identified in the cytoplasm and nucleus of sustentacular cells and underwent reduction in the neoplasias.CONCLUSIONS:
Chromogranin was proven to be a generic marker for neuroendocrine tumors; S100 protein was positive in all 8 cases and the AgKi67 had low positivity in all cases
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Paraganglioma
/
Biomarcadores de Tumor
/
Neoplasias de Cabeza y Cuello
/
Proteínas de Neoplasias
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
São Paulo med. j
Asunto de la revista:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
Medicina
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Año:
2001
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Hospital Heliópolis/BR
/
Universidade de Säo Paulo/BR
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