Behaviour of oligodendrocytes and Schwann cells in an experimental model of toxic demyelination of the central nervous system
Arq. neuropsiquiatr
;
59(2B): 358-361, Jun. 2001. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-286416
RESUMO
Oligodendrocytes and Schwann cells are engaged in myelin production, maintenance and repairing respectively in the central nervous system (CNS) and the peripheral nervous system (PNS). Whereas oligodendrocytes act only within the CNS, Schwann cells are able to invade the CNS in order to make new myelin sheaths around demyelinated axons. Both cells have some limitations in their activities, i.e. oligodendrocytes are post-mitotic cells and Schwann cells only get into the CNS in the absence of astrocytes. Ethidium bromide (EB) is a gliotoxic chemical that when injected locally within the CNS, induce demyelination. In the EB model of demyelination, glial cells are destroyed early after intoxication and Schwann cells are free to approach the naked central axons. In normal Wistar rats, regeneration of lost myelin sheaths can be achieved as early as thirteen days after intoxication; in Wistar rats immunosuppressed with cyclophosphamide the process is delayed and in rats administered cyclosporine it may be accelerated. Aiming the enlightening of those complex processes, all events concerning the myelinating cells in an experimental model are herein presented and discussed
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Células de Schwann
/
Enfermedades del Sistema Nervioso Central
/
Oligodendroglía
/
Enfermedades Desmielinizantes
/
Vaina de Mielina
Límite:
Animales
Idioma:
Inglés
Revista:
Arq. neuropsiquiatr
Asunto de la revista:
Neurología
/
Psiquiatria
Año:
2001
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Bandeirante/BR
/
Universidade Estadual de Campinas/BR
/
Universidade Federal de Pelotas/BR
/
Universidade Federal de Santa Maria/BR
/
Universidade Säo Paulo/BR
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