Níveis plasmáticos de marcadores imunoinflamatórios na aterosclerose coronaria primária e na reestenose coronaria pós-angioplastia / Plasma levels of immunoinflammatory markers in De Novo coronary atherosclerosis and coronary restenosis postangioplasty
Arq. bras. cardiol
;
76(5): 379-389, May 2001. graf, tab
Artículo
en Portugués, Inglés
| LILACS
| ID: lil-288789
RESUMO
OBJECTIVE:
To compare circulating plasma levels of immunoinflammatory markers in patients with known de novo coronary artery disease and patients with postangioplasty restenosis.METHODS:
Using enzymatic immunoabsorbent assay, we measured plasma levels of soluble interleukin-2 receptosr, tumor necrosis factor alpha, and soluble tumor necrosis alpha receptors I and II in 11 patients with restenosis postcoronary angioplasty (restenosis group), in 10 patients with primary atherosclerosis (de novo group) who were referred for coronary angiography because of stable or unstable angina, and in 9 healthy volunteers (control group). Levels of soluble interleukin-2 receptors were significantly higher in the de novo group compared with that in the restenosis and control groups. Levels were also higher in the restenosis group compared with that in the control group. Plasma levels of tumor necrosis alpha and receptor levels were significantly higher in the de novo group compared to with that in the restenosis and control groups, but levels in the restenosis group were not different from that in the controls.CONCLUSION:
Coronary artery disease, either primary or secondary to restenosis, is associated with significant immunoinflammatory activity, which can be assessed by examining the extent of circulating plasma levels of inflammatory markers. Moreover, patients with de novo lesions appear to have increased inflammatory activity compared with patients with restenosis
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Enfermedad de la Arteria Coronaria
/
Receptores de Interleucina-2
/
Factor de Necrosis Tumoral alfa
/
Angioplastia de Balón
Tipo de estudio:
Estudio observacional
/
Factores de riesgo
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
/
Portugués
Revista:
Arq. bras. cardiol
Asunto de la revista:
Cardiología
Año:
2001
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Federal University of Rio Grande do Sul/BR
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