Lamivudine therapy for hepatitis B in renal transplantation
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;35(2): 199-203, Feb. 2002. tab
Article
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| LILACS
| ID: lil-303547
Biblioteca responsable:
BR1.1
RESUMO
Antiviral therapies are associated with an increased risk of acute rejection in transplant patients. The aim of the present study was to evaluate the efficacy and safety of lamivudine therapy for hepatitis B virus (HBV) infection in renal transplant patients. Six patients were included in this study. They received 150 mg/day of lamivudine during a follow-up period of 24 months. The laboratory tests monitored were HBV DNA, HBsAg, HBeAg, ALT, gamma-GT, serum creatinine and blood cyclosporine levels. The HBV DNA became undetectable in four patients as early as in the third month of treatment. After six months, the viral load was also negative in the other two patients, and remained so until 18 months of follow-up. The medication was well tolerated with no major side effects. Lamivudine was safe and effective in blocking HBV replication in renal transplant patients without any apparent increase in the risk of graft failure for the 24-month period of study
Texto completo:
1
Índice:
LILACS
Asunto principal:
Trasplante de Riñón
/
Inhibidores de la Transcriptasa Inversa
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Lamivudine
/
Rechazo de Injerto
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Hepatitis B
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Braz. j. med. biol. res
/
Rev. bras. pesqui. méd. biol
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
2002
Tipo del documento:
Article