Efeitos da sibutramina no tratamento da obesidade em pacientes com hipertensão arterial / Effects of sibutramine on the treatment of obesity in patients with arterial hypertension
Arq. bras. cardiol
;
78(2): 172-180, Feb. 2002. tab, graf
Artículo
en Portugués, Inglés
| LILACS
| ID: lil-303902
ABSTRACT
OBJECTIVE:
To assess the effects of weight reduction with 10mg of sibutramine or placebo on blood pressure during 24 hours (ambulatory blood pressure monitoring), on left ventricular mass, and on antihypertensive therapy in 86 obese and hypertensive patients for 6 months.METHODS:
The patients underwent echocardiography, ambulatory blood pressure monitoring, and measurement of the levels of hepatic enzymes prior to and after treatment with sibutramine or placebo.RESULTS:
The group using sibutramine had a greater weight loss than that using placebo (6.7 percent versus 2.5 percent; p<0.001), an increase in heart rate (78.3±7.3 to 82±7.9 bpm; p=0.02), and a reduction in the left ventricular mass/height index (105±29.3 versus 96.6±28.58 g/m; p=0.002). Both groups showed similar increases in the levels of alkaline phosphatase and comparable adjustments in antihypertensive therapy; blood pressure, however, did not change.CONCLUSION:
The use of sibutramine caused weight loss and a reduction in left ventricular mass in obese and hypertensive patients with no interference with blood pressure or with antihypertensive therapy
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Depresores del Apetito
/
Ciclobutanos
/
Hipertensión
/
Obesidad
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio observacional
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
/
Portugués
Revista:
Arq. bras. cardiol
Asunto de la revista:
Cardiología
Año:
2002
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Federal de Säo Paulo/BR
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