Ulceração de anastomose esôfago-entérica causada por alendronato / Esophagus-enteric anastomosis ulceration caused by alendronate
Arq. gastroenterol
;
38(2): 129-131, abr.-jun. 2001. ilus
Artículo
en Portugués
| LILACS
| ID: lil-305369
RESUMO
BACKGROUND:
Alendronate sodium is an aminobisphosphonate indicated for the treatment of osteoporosis in post-menopausal women and has been associated with esophagitis in many reports. Esophageal stenosis, gastrointestinal symptoms as dyspepsia, nausea, vomiting and abdominal pain could be present.OBJECTIVE:
Report a case of a patient who underwent total gastrectomy with Y-en-Roux anastomosis for a gastric carcinoid tumor and developed an esophagus-enteric anastomosis ulceration after the use of alendronate. PATIENT ANDMETHOD:
A 63-year-old woman started medical therapy with alendronate in a dose of 10 mg daily. After a period of one month of medical treatment with this drug she began to complain of dysphagic symptoms and abdominal pain. She was submitted to endoscopic examination that showed an esophageal ulceration, an enteric ulceration of the anastomosis and an esophageal stenosis.RESULTS:
Medical treatment with alendronate was discontinued and the symptom of abdominal pain disappeared. The intensity of dysphagia has decreased. The ulcerated lesion remitted although esophageal stenosis did not. The patient was subsequently treated with esophagus-enteric anastomosis dilation. She improved in her general state and nowadays she is free of symptoms.CONCLUSION:
Alendronate sodium could cause lesions of the inferior esophageal portion or in distal segments of the gastrointestinal tube, in patients with a fast gastrointestinal transit. Special attention must be given to gastrectomized patients that use this drug because of the possibility to develop mucosal lesions in the enteric anastomosed part and its fearful complications as stenosis.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Osteoporosis
/
Neoplasias Gástricas
/
Úlcera
/
Alendronato
/
Enfermedades del Esófago
/
Enfermedades Intestinales
Límite:
Femenino
/
Humanos
Idioma:
Portugués
Revista:
Arq. gastroenterol
Asunto de la revista:
Gastroenterologia
Año:
2001
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Endocenter/BR
/
Universidade Federal da Paraíba/BR
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