Anti-trypanosomal activity of pentacyclic triterpenes isolated from Austroplenckia populnea (Celastraceae)
Rev. Inst. Med. Trop. Säo Paulo
;
44(2): 109-112, Mar.-Apr. 2002. tab
Artículo
en Inglés
| LILACS
| ID: lil-308015
ABSTRACT
Four pentacyclic triterpenes isolated from Austroplenckia populnea and four compounds of known anti T. cruzi or anti-malarial activity were tested. Of those triterpenes tested 20alpha-hydroxy-tingenone showed high activity, epikatonic acid was less active, while populnilic and populninic acids were inactive against the trypanosome of the subgenus Schizotrypanum tested. Benzonidazole, nifurtimox, ketoconazole and primaquine presented a remarkable dose-dependent inhibitory effect reaching practically to a total growth inhibition of the parasite at the end of incubation time. The trypanosome tested appear to be a suitable model for preliminary screen for anti T. (S.) cruzi compounds
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Triterpenos
/
Tripanocidas
/
Trypanosoma cruzi
Límite:
Animales
Idioma:
Inglés
Revista:
Rev. Inst. Med. Trop. Säo Paulo
Asunto de la revista:
Medicina Tropical
Año:
2002
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
UFMG/BR
Similares
MEDLINE
...
LILACS
LIS