Your browser doesn't support javascript.
loading
Lung clearance of 99mTc-DTPA in systemic lupus erythematosus
Dalcin, P. T. R; Barreto, S. S. M; Cunha, R. D; Xavier, R. M; Brenol, J. C. T; Marroni, B. J.
  • Dalcin, P. T. R; Universidade Federal do Rio Grande do Sul. Hospital de Clínicas de Porto Alegre. Departamento de Medicina Interna. Porto Alegre. BR
  • Barreto, S. S. M; Universidade Federal do Rio Grande do Sul. Hospital de Clínicas de Porto Alegre. Departamento de Medicina Interna. Porto Alegre. BR
  • Cunha, R. D; Universidade Federal do Rio Grande do Sul. Hospital de Clínicas de Porto Alegre. Serviço de Medicina Nuclear. Porto Alegre. BR
  • Xavier, R. M; Universidade Federal do Rio Grande do Sul. Hospital de Clínicas de Porto Alegre. Departamento de Medicina Interna. Porto Alegre. BR
  • Brenol, J. C. T; Universidade Federal do Rio Grande do Sul. Hospital de Clínicas de Porto Alegre. Departamento de Medicina Interna. Porto Alegre. BR
  • Marroni, B. J; Universidade Federal do Rio Grande do Sul. Hospital de Clínicas de Porto Alegre. Serviço de Medicina Nuclear. Porto Alegre. BR
Braz. j. med. biol. res ; 35(6): 663-668, June 2002. tab
Artículo en Inglés | LILACS | ID: lil-309511
ABSTRACT
The early demonstration of lung involvement in systemic lupus erythematosus (SLE) patients is a difficult but important task. In the present study we attempted to identify abnormalities in pulmonary clearance of 99mTc-DTPA in SLE, correlating their clearance data with clinical findings and disease activity. Forty-six consecutive SLE patients with and without active disease (LACC score) and 30 normal volunteers were studied. All subjects were submitted to pulmonary scintigraphy with 99mTc-DTPA to evaluate the pulmonary clearance, and to a chest X-ray, and SLE patients were submitted to tests of disease activity, spirometry, arterial blood gases and tests to assess acute-phase proteins. Pulmonary clearance was faster in SLE patients with active disease when compared to normal controls [half-life of 67.04 min (51.52-82.55 min) in active SLE versus 85.87 min (78.85-92.87 min) in controls, P<0.05] and there was a higher frequency of abnormal clearance rates in patients with active disease (11 of 26 patients, 42.3 percent) when compared with SLE patients without disease activity (2 of 20 patients, 10 percent) (P = 0.04). A significant correlation was observed between the clearance rates and cough (P<0.05), but not between the clearance rates and dyspnea symptoms or radiological findings, duration of SLE disease, antinuclear antibody titers and patterns, C-reactive protein or anti-double stranded DNA antibodies. We conclude that the pulmonary clearance of 99mTc-DTPA is increased in SLE patients with active disease
Asunto(s)
Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Pentetato de Tecnecio Tc 99m / Pulmón / Lupus Eritematoso Sistémico Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Adolescente / Adulto / Femenino / Humanos / Masculino Idioma: Inglés Revista: Braz. j. med. biol. res Asunto de la revista: Biologia / Medicina Año: 2002 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade Federal do Rio Grande do Sul/BR

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Pentetato de Tecnecio Tc 99m / Pulmón / Lupus Eritematoso Sistémico Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Adolescente / Adulto / Femenino / Humanos / Masculino Idioma: Inglés Revista: Braz. j. med. biol. res Asunto de la revista: Biologia / Medicina Año: 2002 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade Federal do Rio Grande do Sul/BR