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Effect of calcium intake on urinary oxalate excretion in calcium stone-forming patients
Nishiura, J. L; Martini, L. A; Mendonça, C. O. G; Schor, N; Heilberg, I. P.
  • Nishiura, J. L; Universidade Federal de Säo Paulo. Disciplina de Nefrologia. Säo Paulo. BR
  • Martini, L. A; Universidade Federal de Säo Paulo. Disciplina de Nefrologia. Säo Paulo. BR
  • Mendonça, C. O. G; Universidade Federal de Säo Paulo. Disciplina de Nefrologia. Säo Paulo. BR
  • Schor, N; Universidade Federal de Säo Paulo. Disciplina de Nefrologia. Säo Paulo. BR
  • Heilberg, I. P; Universidade Federal de Säo Paulo. Disciplina de Nefrologia. Säo Paulo. BR
Braz. j. med. biol. res ; 35(6): 669-675, June 2002. ilus, tab
Artículo en Inglés | LILACS | ID: lil-309515
RESUMO
Dietary calcium lowers the risk of nephrolithiasis due to a decreased absorption of dietary oxalate that is bound by intestinal calcium. The aim of the present study was to evaluate oxaluria in normocalciuric and hypercalciuric lithiasic patients under different calcium intake. Fifty patients (26 females and 24 males, 41 ± 10 years old), whose 4-day dietary records revealed a regular low calcium intake (<=500 mg/day), received an oral calcium load (1 g/day) for 7 days. A 24-h urine was obtained before and after load and according to the calciuria under both diets, patients were considered as normocalciuric (NC, N = 15), diet-dependent hypercalciuric (DDHC, N = 9) or diet-independent hypercalciuric (DIHC, N = 26). On regular diet, mean oxaluria was 30 ± 14 mg/24 h for all patients. The 7-day calcium load induced a significant decrease in mean oxaluria compared to the regular diet in NC and DIHC (20 ± 12 vs 26 ± 7 and 27 ± 18 vs 32 ± 15 mg/24 h, respectively, P<0.05) but not in DDHC patients (22 ± 10 vs 23 ± 5 mg/24 h). The lack of an oxalate decrease among DDHC patients after the calcium load might have been due to higher calcium absorption under higher calcium supply, with a consequent lower amount of calcium left in the intestine to bind with oxalate. These data suggest that a long-lasting regular calcium consumption <500 mg was not associated with high oxaluria and that a subpopulation of hypercalciuric patients who presented a higher intestinal calcium absorption (DDHC) tended to hyperabsorb oxalate as well, so that oxaluria did not change under different calcium intake
Asunto(s)
Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Oxalatos / Calcio de la Dieta / Cálculos Renales / Calcio Límite: Adulto / Femenino / Humanos / Masculino Idioma: Inglés Revista: Braz. j. med. biol. res Asunto de la revista: Biologia / Medicina Año: 2002 Tipo del documento: Artículo / Documento de proyecto País de afiliación: Brasil Institución/País de afiliación: Universidade Federal de Säo Paulo/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Oxalatos / Calcio de la Dieta / Cálculos Renales / Calcio Límite: Adulto / Femenino / Humanos / Masculino Idioma: Inglés Revista: Braz. j. med. biol. res Asunto de la revista: Biologia / Medicina Año: 2002 Tipo del documento: Artículo / Documento de proyecto País de afiliación: Brasil Institución/País de afiliación: Universidade Federal de Säo Paulo/BR