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Evaluation of Gilles de la Tourette syndrome with [99mTc] HMPAO Brain SPECT
Carreira, LCTF; Santos, A. O; Juarez, B. A; Leite, H. A; Lima, M. C. L; Ramos, C. D; Camargo, E. E.
  • Carreira, LCTF; Universidade do Estado de Campinas. Division of Nuclear Medicine. Department of Radiology. BR
  • Santos, A. O; Universidade do Estado de Campinas. Division of Nuclear Medicine. Department of Radiology. BR
  • Juarez, B. A; Universidade do Estado de Campinas. Division of Nuclear Medicine. Department of Radiology. BR
  • Leite, H. A; Universidade do Estado de Campinas. Division of Neurosurgery. BR
  • Lima, M. C. L; Universidade do Estado de Campinas. Division of Nuclear Medicine. Department of Radiology. BR
  • Ramos, C. D; Universidade do Estado de Campinas. Division of Nuclear Medicine. Department of Radiology. BR
  • Camargo, E. E; Universidade do Estado de Campinas. Division of Nuclear Medicine. Department of Radiology. BR
Rev. med. nucl. Alasbimn j ; 4(15)abr. 2002. ilus, tab
Artículo en Inglés | LILACS | ID: lil-313225
RESUMO
Gilles de la Tourette syndrome (GLTS) is a disorder characterized by tics and several behavioral disturbances. Although GLTS is a relatively common disorder, little is known about its pathophysiology. Previous studies with SPECT and PET were performed in a small number of patients and have shown some discordant data. The aim of this study is to evaluate brain perfusion abnormalities in patients with GLTS and to correlate them with the clinical manifestations of the syndrome. Twenty-eight patients were submitted to brain [99mTc]-HMPAO SPECT. 82 percent of the patients had abnormal studies. The most frequent finding was perfusion abnormalities in the thalami in 16 patients (57 percent) and 85 percent of patients with hyperperfusion of one or both thalami had complex motor tics. This investigation has demonstrated that brain perfusion SPECT is able to identify cortical perfusion abnormalities, associated with clinical symptoms in patients with GLTS. These abnormalities involve the pre-frontal-striatal-thalamic-cortical pathways
Asunto(s)
Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Síndrome de Tourette / Tomografía Computarizada de Emisión de Fotón Único / Exametazima de Tecnecio Tc 99m Tipo de estudio: Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: Rev. med. nucl. Alasbimn j Asunto de la revista: Medicina Nuclear Año: 2002 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade do Estado de Campinas/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Síndrome de Tourette / Tomografía Computarizada de Emisión de Fotón Único / Exametazima de Tecnecio Tc 99m Tipo de estudio: Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: Rev. med. nucl. Alasbimn j Asunto de la revista: Medicina Nuclear Año: 2002 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade do Estado de Campinas/BR