Comparison between adventitial and intimal inflammation of ruptured and nonruptured atherosclerotic plaques in human coronary arteries
Arq. bras. cardiol
;
79(1): 20-24, July 2002. ilus, tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-316163
ABSTRACT
OBJECTIVE:
To verify the possible role of adventitial inflammation in atherosclerotic plaque vulnerability and coronary artery remodelling.METHODS:
We compared the mean numbers of lymphocytes in the adventitia and in the plaque of ruptured thrombosed and stable equi-stenotic coronary segments of 34 patients who died due to acute myocardial infarction. We also analysed adventitial microvessels, adventitial fibrosis and the external elastic membrane.RESULTS:
In the adventitia, the numbers of lymphocytes and microvessels/mm² were 69.5±88.3 and 60.9± 32.1 in culprit lesions and 16.4 ± 21.1 and 44.3±16.1 in stable lesions (p<0.05); within the plaques, the mean number of lymphocytes was 24±40.8 in culprit lesions and 10.9±13.2 in stable ones (p=0.17). The mean percent area of adventitial fibrosis/cross-sectional area of the vessel was significantly lower in unstable plaques (p<0.001). The confocal images showed holes in the external elastic membrane.CONCLUSION:
Unstable plaques exhibit chronic pan-arteritis, accompanied by enlargement, medial thinning, and less fibrosis than in stable lesions, which is compatible with vessel aneurysm. Adventitial inflammation may contribute significantly to atheroma instability
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Enfermedad de la Arteria Coronaria
/
Inflamación
Límite:
Humanos
Idioma:
Inglés
Revista:
Arq. bras. cardiol
Asunto de la revista:
Cardiología
Año:
2002
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
University of Säo Paulo/BR
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