Dexketoprofeno: aine preferencial inhibidor COX-1, sin lesión gastrointestinal, en ratas / Dexketoprofene, selective cox-1 inhibitor nsaids, without gastrointestinal injury in rats
Acta gastroenterol. latinoam
;
32(1): 20-17, maiy 2002. tab
Artículo
en Español
| LILACS
| ID: lil-316193
RESUMO
Dexketoprofene (De) NSAID was studied as a selective COX-1 inhibitor in comparison with Ketorolac (Ke), a mainly COX-1 inhibitor. De and Ke were administered to different groups of animals in a dose-dependent manner, i.e., 3-15 and 25 mgs/kg. The gastrointestinal mucosa damage was macroscopically and microscopically quantified at 24 hs, as well as leukocyte infiltration (LI) and neosinophilia. Similarly, Indomethacin (Indo) damage (COX-1-COX-2), with 25 mgs/kg. Dose was compared. On the other hand, De and Ke at inhibitory selective COX-1 dose (3 mg/kg) plus Celecoxib, selective COX-2 inhibitor, yielding no gastrointestinal damage, with decreased LI and without neutrophilia, the same as Ke (n.s.). Similarly De at higher dose (2.5 mgs/kg), produced minimal gastrointestinal lesions, showing a preferential COX-1 inhibitor behavior. Ke and Indo produced important gastrointestinal necrotic and erosive lesions with remarkable LI and neutrophilia (p < 0.001). On the other hand, COX-1 De dose plus Celecoxib produced evident gastrointestinal lesions, increased LI and neutrophilia, the same as Indo, pointing out that the gastrointestinal damage is due to COX-1 and COX-2 inhibition
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Índice:
LILACS (Américas)
Asunto principal:
Trometamina
/
Cetoprofeno
/
Inhibidores de la Ciclooxigenasa
/
Mucosa Intestinal
Límite:
Animales
/
Humanos
Idioma:
Español
Revista:
Acta gastroenterol. latinoam
Asunto de la revista:
Gastroenterologia
Año:
2002
Tipo del documento:
Artículo
País de afiliación:
Argentina
Institución/País de afiliación:
Facultad de Ciencias Médicas/AR
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