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Imunonutrição em colite experimenta: efeitos benéficos dos ácidos graxos ômega-3 / Immunonutrition in experimental colitis: benefical effects of omega-3 fatty acids
Campos, Fábio Guilherme; Waitzberg, Dan L; Logulo, Angela Flávia; Torrinhas, Raquel Susana; Teixeira, William Gemio Jacobsen; Habr-Gama, Angelita.
Afiliación
  • Campos, Fábio Guilherme; Universidade de São Paulo. Faculdade de Medicina. São Paulo. BR
  • Waitzberg, Dan L; Universidade de São Paulo. Faculdade de Medicina. São Paulo. BR
  • Logulo, Angela Flávia; Universidade de São Paulo. Faculdade de Medicina. São Paulo. BR
  • Torrinhas, Raquel Susana; Universidade de São Paulo. Faculdade de Medicina. São Paulo. BR
  • Teixeira, William Gemio Jacobsen; Universidade de São Paulo. Faculdade de Medicina. São Paulo. BR
  • Habr-Gama, Angelita; Universidade de São Paulo. Faculdade de Medicina. São Paulo. BR
Arq. gastroenterol ; Arq. gastroenterol;39(1): 48-54, jan.-mar. 2002. ilus, tab
Article en Pt | LILACS | ID: lil-316279
Biblioteca responsable: BR1.1
RESUMO
Recent data have given emphasis to the benefits of immunonutrition with omega-3 fatty acids (n-3 FA) in various clinical situations. This work presents the results of parenteral administration of different lipid emulsions in experimental acute colitis and reviews the pertinent literature.

METHODS:

Seventy-four adult male Wistar rats were randomized in six groups that had 10% acetic acid-induced colitis (except CS). During 7 days, control groups CS (without colitis) and CC (with colitis) received physiological solution and the others received specific lipid emulsion by a central venous catheter (0.5 mL/h). The n-3/n-6 FA ratio and lipidic compositions were group L--17.7 (LCT, n = 12), M--17.0 (MCT and LCT, n = 12), LW-3--14.5 (LCT plus FO, n = 12) and MW-3--13.0 (MCT and LCT plus FO, n = 13). Rats were evaluated to assess abdominal and intestinal alterations, macrophage cellularity and colonic concentrations of LTB4, LTC4, PGE2 and TXB2.

RESULTS:

N-3 FA treated rats (LW-3 and MW-3) presented less inflammatory abdominal alterations than CC rats. Mucosal ulcer formation in MW-3 group was the only comparable to CS group. Only CS, M and MW-3 rats presented smaller cellularity than CC group. Comparing to CC group, there were found smaller averages of LTB4 in CS, LW-3 and MW-3 groups, of PGE2 in CS, M and MW-3 groups, and of TXB2 in CS and MW-3 groups. LTC4 averages were not different.

CONCLUSIONS:

1) LCT-containing lipid emulsion with low n-3/n-6 ratio do not modify inflammatory colitis derived manifestations; 2) the association of MCT/LCT-containing lipid emulsion with fish oil with high n-3/n-6 ratio impels great beneficial impact, attenuating morphological and inflammatory consequences and decreasing colonic concentrations of proinflammatory mediators
Asunto(s)
Texto completo: 1 Índice: LILACS Asunto principal: Ácidos Grasos Omega-3 / Colitis / Emulsiones Grasas Intravenosas Límite: Animals Idioma: Pt Revista: Arq. gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2002 Tipo del documento: Article
Texto completo: 1 Índice: LILACS Asunto principal: Ácidos Grasos Omega-3 / Colitis / Emulsiones Grasas Intravenosas Límite: Animals Idioma: Pt Revista: Arq. gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2002 Tipo del documento: Article