Recurrent and de novo non-alcoholic steatohepatitis following orthotopic liver transplantation
Arq. gastroenterol
;
38(4): 247-253, out.-dez. 2001. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-316289
RESUMO
Non-alcoholic steatohepatitis was coined in 1980 to describe pathological and clinical features of non-alcoholic disease associated with pathological features, commonly seen in alcoholic-liver disease itself. It is now a well-recognised cause of end-stage liver disease and a rare cause of orthotopic liver transplantation. A small number of cases with recurrent non-alcoholic steatohepatitis following liver transplantation have been reported, however de novo non-alcoholic steatohepatitis in the liver allograft is not well recognised. AIMS/RESULTS:
We report four cases of non-alcoholic steatohepatitis following orthotopic liver transplantation describing the factors related with the pathology. The recurrence of fatty infiltration occurred within 21 months and transition from mild steatosis to non-alcoholic steatohepatitis and early fibrosis was observed within 60 months post transplant in all four patients. All four cases had association with one or multiples risk factors (obesity, type 2 diabetes and/or hyperlipidemia).CONCLUSIONS:
Management of this risk factors may play a therapeutic role in the prevention of recurrent and de novo non-alcoholic steatohepatitis following orthotopic liver transplantation
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Complicaciones Posoperatorias
/
Trasplante de Hígado
/
Diabetes Mellitus
/
Hígado Graso
/
Hepatitis
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Arq. gastroenterol
Asunto de la revista:
Gastroenterologia
Año:
2001
Tipo del documento:
Artículo
/
Congreso y conferencia
País de afiliación:
Reino Unido
Institución/País de afiliación:
Queen Elizabeth Hospital/GB
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