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Intravenous chlorpromazine in the acute treatment of episodic tension-type headache: a randomized, placebo controlled, double-blind study
Bigal, Marcelo Eduardo; Bordini, Carlos Alberto; Speciali, José Geraldo.
  • Bigal, Marcelo Eduardo; University of Säo Paulo. School of Medicine at Ribeiräo Preto. Department of Neurology. Ribeiräo Preto. BR
  • Bordini, Carlos Alberto; University of Säo Paulo. School of Medicine at Ribeiräo Preto. Department of Neurology. Ribeiräo Preto. BR
  • Speciali, José Geraldo; University of Säo Paulo. School of Medicine at Ribeiräo Preto. Department of Neurology. Ribeiräo Preto. BR
Arq. neuropsiquiatr ; 60(3A): 537-541, Sept. 2002. tab, graf
Artículo en Inglés | LILACS | ID: lil-316629
ABSTRACT
Acute headache is a very frequent symptom, responsible for a significant percentage of caseload at primary care units and emergency rooms. Chlorpromazine is easily available in such settings. The aim of this study is to conduct a randomized, placebo-controlled, double-blind study to assess the efficacy of chlorpromazine on the acute treatment of episodic tension-type headache. We randomized 30 patients to receive placebo (10 ml of saline intravenous injections) and 30 patients to receive 0.1 mg/Kg chlorpromazine intravenously. We used 7 parameters of analgesic evaluation. Patients receiving chlorpromazine showed a statistically significant improvement (p < 0.05 and p < 0.01) of pain compared to placebo, far up to 30 minutes after the drug administration. The therapeutic gain was 36.7 percent in 30 minutes and 56.6 percent in 60 minutes. The number needed to treat (NNT, the reciprocal or the therapeutic gain) was 2.7 in 30 minutes and 1.8 in 60 minutes. There were reductions in the recurrence and in the use of rescue medication in the chlorpromazine group. We can conclude that intravenous chlorpromazine is an effective drug to relief the pain in tension-type headache
Asunto(s)
Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Clorpromazina / Cefalea de Tipo Tensional / Antagonistas de Dopamina Tipo de estudio: Ensayo Clínico Controlado Límite: Adulto / Femenino / Humanos / Masculino Idioma: Inglés Revista: Arq. neuropsiquiatr Asunto de la revista: Neurología / Psiquiatria Año: 2002 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: University of Säo Paulo/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Clorpromazina / Cefalea de Tipo Tensional / Antagonistas de Dopamina Tipo de estudio: Ensayo Clínico Controlado Límite: Adulto / Femenino / Humanos / Masculino Idioma: Inglés Revista: Arq. neuropsiquiatr Asunto de la revista: Neurología / Psiquiatria Año: 2002 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: University of Säo Paulo/BR