Análise dos níveis de homocisteína plasmática em pacientes com angina instável / Analysis of plasma homocysteine levels in patients with unstable angina
Arq. bras. cardiol
;
79(2): 161-172, Aug. 2002. tab, graf
Artículo
en Portugués, Inglés
| LILACS
| ID: lil-317889
RESUMO
OBJECTIVE - To determine the prevalence of hyperhomocystinemia in patients with acute ischemic syndrome of the unstable angina type. METHODS - We prospectively studied 46 patients (24 females) with unstable angina and 46 control patients (19 males), paired by sex and age, blinded to the laboratory data. Details of diets, smoking habits, medication used, body mass index, and the presence of hypertension and diabetes were recorded, as were plasma lipid and glucose levels, C-reactive protein, and lipoperoxidation in all participants. Patients with renal disease were excluded. Plasma homocysteine was estimated using high-pressure liquid chromatography. RESULTS - Plasma homocysteine levels were significantly higher in the group of patients with unstable angina (12.7±6.7 æmol/L) than in the control group (8.7±4.4 æmol/L) (p<0.05). Among males, homocystinemia was higher in the group with unstable angina than in the control group, but this difference was not statistically significant (14.1±5.9 æmol/L versus 11.9±4.2 æmol/L). Among females, however, a statistically significant difference was observed between the 2 groups 11.0±7.4 æmol/L versus 6.4±2.9 æmol/L (p<0.05) in the unstable angina and control groups, respectively. Approximately 24 percent of the patients had unstable angina at homocysteine levels above 15 æmol/L. CONCLUSION - High homocysteine levels seem to be a relevant prevalent factor in the population with unstable angina, particularly among females
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Hiperhomocisteinemia
/
Homocisteína
/
Angina Inestable
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio de etiología
/
Estudio observacional
/
Estudio de prevalencia
Límite:
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
/
Portugués
Revista:
Arq. bras. cardiol
Asunto de la revista:
Cardiología
Año:
2002
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Federal de Säo Paulo/BR
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