Effect of withdrawal from long-term nifedipine administration on open-field habituation in the rat
Braz. j. med. biol. res
;
27(6): 1363-1367, June 1994.
Artículo
en Inglés
| LILACS
| ID: lil-319767
ABSTRACT
The effects of withdrawal from long-term administration of nifedipine (2.5 mg/kg, ip, twice daily for 30 days) on open-field habituation were evaluated in 3-month old male Wistar rats (13-14 animals per group). Habituation was evaluated by the ratio between locomotion or rearing frequencies obtained in the second and the first open-field session for each animal. Nifedipine treatment did not modify the locomotion ratio (with a mean +/- SEM ratio of 0.66 +/- 0.12 for control and 0.45 +/- 0.08 for nifedipine-treated group) nor the rearing ratio (with a mean +/- SEM ratio of 0.51 +/- 0.12 for control and 0.62 +/- 0.18 for nifedipine-treated group). The possible factors underlying the discrepancy between the present results and the commonly reported positive effects of calcium channel blockers on memory are discussed.
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Índice:
LILACS (Américas)
Asunto principal:
Nifedipino
/
Habituación Psicofisiológica
/
Memoria
Límite:
Animales
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
1994
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Escola Paulista de Medicina/BR
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