Studies on the replication of Mayaro virus grown in interferon treated cells
Mem. Inst. Oswaldo Cruz
;
89(4): 619-623, Oct.-Dec. 1994.
Artículo
en Inglés
| LILACS
| ID: lil-319929
RESUMO
Mayaro virus grown in interferon treated infected cells has been characterized with regard to its ability to replicate in vertebrate (TC7) and invertebrate (Aedes albopictus) cells. Virus purified from interferon treated TC7 cells adsorbs and penetrates to the same extent as the control virus. During infection, these virus particles caused inhibition of host protein synthesis and synthesized the same spectrum of viral proteins as normal virus. This population however, was apparently more sensitive to interferon treatment. Electron microscopy of TC7 cells showed the presence of numerous aberrant virus particles budding from the plasma membrane.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Replicación Viral
/
Interferón-alfa
/
Alphavirus
Límite:
Animales
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
1994
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Federal do Rio de Janeiro (UFRJ)/BR
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