A novel merozoite surface antigen of Plasmodium falciparum (MSP-3) identified by cellular-antibody cooperative mechanism antigenicity and biological activity of antibodies
Mem. Inst. Oswaldo Cruz
;
89(Suppl.2): 77-80, 1994.
Artículo
en Inglés
| LILACS
| ID: lil-319946
RESUMO
We report the identification of a 48kDa antigen targeted by antibodies which inhibit Plasmodium falciparum in vitro growth by cooperation with blood monocytes in an ADCI assay correlated to the naturally acquired protection. This protein is located on the surface of the merozoite stage of P. falciparum, and is detectable in all isolates tested. Epidemiological studies demonstrated that peptides derived from the amino acid sequence of MSP-3 contain potent B and T-cell epitopes recognized by a majority of individuals living in endemic areas. Moreover human antibodies either purified on the recombinant protein, or on the synthetic peptide MSP-3b, as well as antibodies raised in mice, were all found to promote parasite killing mediated by monocytes.
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LILACS (Américas)
Asunto principal:
Plasmodium falciparum
/
Inmunoglobulina M
/
Proteínas Protozoarias
/
Antígenos de Superficie
Límite:
Animales
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
1994
Tipo del documento:
Artículo
País de afiliación:
Francia
Institución/País de afiliación:
Institut Pasteur/FR
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