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Subtelomeric structure of Plasmodium falciparum chromosomes
Scotti, R; Pace, T; Roca, L; Frontali, C.
  • Scotti, R; Istituto Superiore di Sanità. Rome. IT
  • Pace, T; Istituto Superiore di Sanità. Rome. IT
  • Roca, L; Istituto Superiore di Sanità. Rome. IT
  • Frontali, C; Istituto Superiore di Sanità. Rome. IT
Mem. Inst. Oswaldo Cruz ; 89(Suppl.2): 31-32, 1994.
Artículo en Inglés | LILACS | ID: lil-319956
ABSTRACT
Previous studies of subtelomeric regions in Plasmodium berghei led to the identification of subtelomeric repeats (2.3kb long) present in a variable number at many chromosomal ends. Both loss and increase in 2.3kb-repeat copy number are involved in chromosome-size polymorphisms. Subtelomeric losses leading to chromosome-size polymorphisms have been described by several authors in P.falciparum where the structure of subtelomeric regions is not known in detail. We therefore undertook their characterisation, by means of chromosome walking and jumping techniques, starting from the telomere-flanking sequence present in pPftel.1, the P.falciparum telomeric clone described by Vernick and McCutchan (1988). The results indicate that at least 20 (out of 28) chromosomal ends in P.falciparum 3D7 chromosomes share a subtelomeric region, about 40kb long, covering (but not limited to) the Rep20 region. Non repetitive, AT-rich portions flanking the Rep20 region on both sides are also conserved at most chromosomal ends.
Asunto(s)
Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Plasmodium falciparum / Telómero / Genes Protozoarios Tipo de estudio: Estudio pronóstico Límite: Animales Idioma: Inglés Revista: Mem. Inst. Oswaldo Cruz Asunto de la revista: Medicina Tropical / Parasitología Año: 1994 Tipo del documento: Artículo País de afiliación: Italia Institución/País de afiliación: Istituto Superiore di Sanità/IT

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Plasmodium falciparum / Telómero / Genes Protozoarios Tipo de estudio: Estudio pronóstico Límite: Animales Idioma: Inglés Revista: Mem. Inst. Oswaldo Cruz Asunto de la revista: Medicina Tropical / Parasitología Año: 1994 Tipo del documento: Artículo País de afiliación: Italia Institución/País de afiliación: Istituto Superiore di Sanità/IT