Serum factors inhibitory for in vitro development of Plasmodium falciparum blood-stage parasites
Mem. Inst. Oswaldo Cruz
;
89(Suppl.2): 17-21, 1994.
Artículo
en Inglés
| LILACS
| ID: lil-319959
ABSTRACT
Sera from 29 individuals residing in a malaria-endemic region of Colombia were evaluated by an inhibition assay for their capacity to retard the growth of Plasmodium falciparum in vitro. The inhibitory activity was found to be independent of antibody activity. Furthermore, the degree of inhibition of parasite development was variable, depending on the parasite isolate used for the assay and the season of malaria transmission. We selected sera with high inhibitory activity and carried out partial analytical characterization by anion exchange fast protein liquid chromatography (FPLC) to identify the chemical nature of the inhibitory factor(s). The results suggested that the in vitro inhibitory activity might result from the additive effect of different molecules. It appears that these molecules could be non-specifically induced by stimulation of the immune system, they seem to play a role in the immunity to malaria.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Plasmodium falciparum
/
Sueros Inmunes
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
1994
Tipo del documento:
Artículo
País de afiliación:
Colombia
Institución/País de afiliación:
Universidad del Valle/CO
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