ABO, Lewis, secretor and non-secretor phenotypes in patients infected or uninfected by the Helicobacter pylori bacillus
São Paulo med. j
;
120(2): 55-58, Mar. 2002. tab
Artículo
en Inglés
| LILACS
| ID: lil-320716
RESUMO
CONTEXT Epidemiological studies have demonstrated higher frequencies of the O blood group and the non-secretor phenotype of ABH antigens among patients suffering from peptic ulcers. Since Helicobacter pylori has been established as the main etiological factor in this disease, controversies about the associations of the ABO and Lewis blood group phenotypes and secretor and non-secretor phenotypes in relation to susceptibility towards infection by this bacillus have been presented. OBJECTIVE:
To verify the frequencies of ABO, Lewis blood group phenotypes, secretor and non-secretor phenotypes in patients infected or uninfected by H. pylori.DESIGN:
Cross-sectional study.SETTING:
Outpatient clinic.PARTICIPANTS:
One hundred and twenty patients with dyspeptic symptoms who underwent endoscopy.MAIN MEASUREMENTS ABO and Lewis blood group phenotypes were determined by a standard hemagglutination test and the secretor and non-secretor phenotypes were evaluated by saliva samples using the inhibitor hemagglutination test.RESULTS:
The diagnosis of infection, made via breath and urea tests and confirmed using polymerase chain reaction (PCR) in gastric biopsy fragments, showed the presence of H. pylori in 61.7 percent of the patients and absence in 38.3 percent. The differences between the frequencies of the ABO blood group phenotypes among infected (A 27.0 percent; B 12.2 percent; AB 4.0 percent and O 56.8 percent) and uninfected patients (A 58.7 percent; B 13.0 percent; AB 4.3 percent and O 24.0 percent) were significant. The Lewis blood type, secretor and non-secretor phenotypes showed homogeneous distribution between the groups of patients analyzed.CONCLUSIONS:
Our results suggest that the infection of H. pylori can be related to ABO blood groups but not to the Lewis blood group nor to secretor and non-secretor phenotypes
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Sistema del Grupo Sanguíneo ABO
/
Helicobacter pylori
/
Infecciones por Helicobacter
/
Dispepsia
/
Antígenos del Grupo Sanguíneo de Lewis
Tipo de estudio:
Estudio observacional
/
Estudio de prevalencia
/
Factores de riesgo
Límite:
Adolescente
/
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
São Paulo med. j
Asunto de la revista:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
Medicina
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Año:
2002
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Faculty of Medicine of Säo José do Rio Preto/BR
/
Hemocenter of Säo José do Rio Preto/BR
/
Säo Paulo State University/BR
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