Effects of ondansetron on respiratory pattern and sensation of experimentally induced dyspnea
São Paulo med. j
;
120(5): 141-145, July 2002. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-321232
RESUMO
CONTEXT Dyspnea remains a therapeutic challenge, especially in chronic respiratory conditions. Recent studies have shown that the induction of unpleasant dyspnea sensations activates areas in the insular cortex. OBJECTIVE:
This study was designed to investigate the potential effects of ondansetron, a potent anti-serotonin agent, on induced dyspnea sensation. TYPE OF STUDY A randomized double blind study.SETTING:
Pulmonary Function Laboratory of Hospital das Clínicas de Ribeiräo Preto.PARTICIPANTS:
Ten healthy male volunteers (mean age ± standard error = 23.1 ± 0.41 years) without respiratory diseases and showing normal spirometric tests.INTERVENTIONS:
Uncomfortable breathing was induced in the volunteers on two different days, via the use of inspiratory resistors (loads of 0, 7, 14 and 21 cm H2O/l/sec) and breathholding, two hours after taking 8 mg of ondansetron (Ond) or placebo (Plac). MAIN MEASUREMENTS Respiratory discomfort during breathing under loading was evaluated on a 100-mm visual analog scale. The maximum length of time of voluntary apnea was measured in seconds.RESULTS:
The mean maximum voluntary apnea time did not differ between the ondansetron and placebo days (Plac = 96 ± 6.6 sec vs. Ond = 100 ± 7.9 sec). Ondansetron did not influence the dyspnea sensation induced by different inspiratory loads (0 cm H2O/l/sec Ond = 1.4 mm ± 0.44 vs. Plac = 2.1 ± 0.85 mm; 7 cm H2O/l/sec Ond = 16.6 ± 2.74 mm vs. Plac = 13.7 ± 2.06 mm; 14 cm H2O/l/sec; Ond = 30.5 ± 4.50 mm vs. Plac = 27.1 ± 3.44 mm; 21 cm H2O/l/sec Ond = 50.3 ± 6.72 mm vs. Plac = 49.4 ± 6.72 mm). Ondansetron led to significant decreases in tidal volume under basal conditions and when breathing under the highest inspiratory loading (0 cm H2O/l/sec Ond = 0.83 ± 0.26 l vs. Plac = 1.0 ± 0.28 l; 21 cm H2O/l/sec Ond = 0.86 ± 0.23 l vs. Plac = 1.1 ± 0.22 l)CONCLUSION:
The present results suggest that 5-HT3 receptors do not play an important role in the mediation of dyspnea sensations
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Antagonistas de la Serotonina
/
Ondansetrón
/
Disnea
Tipo de estudio:
Ensayo Clínico Controlado
Límite:
Adulto
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
São Paulo med. j
Asunto de la revista:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
Medicina
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Año:
2002
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Faculdade de Medicina de Ribeiräo Preto/BR
Similares
MEDLINE
...
LILACS
LIS