Gas tonometry for evaluation of gastrointestinal mucosal perfusion: experimental and clinical sepsis. part 2
Acta cir. bras
;
17(5): 281-288, set.-out. 2002. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-322144
RESUMO
Substantial clinical and animal evidences indicate that the mesenteric circulatory bed, particularly the gut mucosa, is highly vulnerable to reductions in oxygen supply and prone to early injury in the course of hemodynamic changes induced by sepsis and septic shock. Gut hypoxia or ischemia is one possible contributing factor to gastrointestinal tract barrier dysfunction that may be associated with the development of systemic inflammatory response and multiple organ dysfunction syndrome, the principal cause of death after sepsis. Monitoring gut perfusion during experimental and clinical sepsis may provide valuable insights over new interventions and therapies highly needed to reduce multiple organ dysfunction and sepsis-related morbidity and mortality. We present our experience with gas tonometry as a monitor of the adequacy of gastrointestinal mucosal perfusion in experimental models sepsis and with the use of vasoactive agents for hemodynamic management in patients with septic shock.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Perfusión
/
Choque Séptico
/
Sepsis
/
Mucosa Intestinal
/
Manometría
Tipo de estudio:
Estudio pronóstico
Idioma:
Inglés
Revista:
Acta cir. bras
Asunto de la revista:
Cirugía General
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2002
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade de Santo Amaro/BR
/
Universidade de Säo Paulo/BR
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