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Signaling triggered by Thy-1 interaction with beta 3 integrin on astrocytes is an essential step towards unraveling neuronal Thy-1 function
Avalos, Ana María; Labra, Cecilia V; Quest, Andrew F G; Leyton, Lisette.
  • Avalos, Ana María; University of Chile. Faculty of Medicine. Institute of Biomedical Sciences. Programs of Morphology. CL
  • Labra, Cecilia V; University of Chile. Faculty of Medicine. Institute of Biomedical Sciences. Programs of Morphology. CL
  • Quest, Andrew F G; University of Chile. Faculty of Medicine. Institute of Biomedical Sciences. Programs of Cell & Molecular Biology. CL
  • Leyton, Lisette; University of Chile. Faculty of Medicine. Institute of Biomedical Sciences. Programs of Morphology. CL
Biol. Res ; 35(2): 231-238, 2002. ilus
Artículo en Inglés | LILACS | ID: lil-323346
RESUMO
Thy-1 is an abundant neuronal glycoprotein in mammals. Despite such prevalence, Thy-1 function remains largely obscure in the absence of a defined ligand. Recently described evidence that Thy-1 interacts with beta 3 integrin on astrocytes will be discussed. Thy-1 binding to beta 3 integrin triggers tyrosine phosphorylation of focal adhesion proteins in astrocytes, thereby promoting focal adhesion formation, cell attachment and spreading. Thy-1 has been reported to modulate neurite outgrowth by triggering a cellular response in neurons. However, our data indicate that Thy-1 can also initiate signaling events that promote adhesion of adjacent astrocytes to the underlying surface. Preliminary results suggest that morphological changes observed in the actin cytoskeleton of astrocytes as a consequence of Thy-1 binding is mediated by small GTPases from the Rho family. Our findings argue that Thy-1 functions in a bimodal fashion, as a receptor on neuronal cells and as a ligand for beta 3 integrin receptor on astrocytes. Since Thy-1 is implicated in the inhibition of neurite outgrowth, signaling events in astrocytes are likely to play an important role in this process
Asunto(s)
Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Glicoproteínas de Membrana Plaquetaria / Transducción de Señal / Astrocitos / Antígenos Thy-1 Tipo de estudio: Factores de riesgo Límite: Animales / Humanos Idioma: Inglés Revista: Biol. Res Asunto de la revista: Biologia Año: 2002 Tipo del documento: Artículo / Documento de proyecto País de afiliación: Chile Institución/País de afiliación: University of Chile/CL

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Glicoproteínas de Membrana Plaquetaria / Transducción de Señal / Astrocitos / Antígenos Thy-1 Tipo de estudio: Factores de riesgo Límite: Animales / Humanos Idioma: Inglés Revista: Biol. Res Asunto de la revista: Biologia Año: 2002 Tipo del documento: Artículo / Documento de proyecto País de afiliación: Chile Institución/País de afiliación: University of Chile/CL