Beta-globin gene cluster haplotypes in Venezuelan sickle cell patients from the State of Aragua
Genet. mol. biol
;
25(1): 21-34, 2002. tab
Artículo
en Inglés
| LILACS
| ID: lil-324981
ABSTRACT
Seven polymorphic sites in the beta-globin gene cluster were analyzed on a sample of 96 chromosomes of Venezuelan sickle cell patients from the State of Aragua. The Benin haplotype was predominant with a frequency of 0.479, followed by the Bantu haplotype (0.406); a minority of cases with other haplotypes was also identified atypical Bantu A2 (0.042), Senegal (0.031), atypical Bantu A7 (0.021) and Saudi Arabia/Indian (0.021) haplotypes; however, the Cameroon haplotype was not identified in this study. Our results are in agreement with the historical records that establish Sudanese and Bantu origins for the African slaves brought into Venezuela
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Haplotipos
/
Globinas
/
Hemoglobina Falciforme
/
Anemia de Células Falciformes
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
País/Región como asunto:
America del Sur
/
Venezuela
Idioma:
Inglés
Revista:
Genet. mol. biol
Asunto de la revista:
Genética
Año:
2002
Tipo del documento:
Artículo
País de afiliación:
Venezuela
Institución/País de afiliación:
Hospital Central de Maracay/VE
/
Universidad Pedagógica Experimental Libertador Maracay/VE
/
Universidad de Carabobo Núcleo Aragua/VE
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