Recent advances in the diagnosis of Schistosoma infection: the detection of parasite DNA
Mem. Inst. Oswaldo Cruz
;
97(suppl.1): 171-172, Oct. 2002. ilus
Artículo
en Inglés
| LILACS
| ID: lil-325016
ABSTRACT
As Schistosoma sp. control programs are chiefly based on treatment of infected population, adequate case finding has a crucial role. The available diagnostic methods are far from ideal, since the search for eggs in stools and the detection of circulating antigens lack sensitivity in low prevalence and post-treatment situations and antibody detection lacks specificity. In most endemic foci, repeated treatment of infected people leaves a number of non-diagnosed and consequently non-treated persons, enough to maintain a persistent residue of 5 to 10 percent prevalence. In an attempt to surpass these diagnostic limitations we have developed a polymerase chain reaction (PCR) for the detection of Schistosoma sp. in feces that, in a first population study, has shown to be more sensitive than three-repeated stool Kato-Katz examination. The PCR may constitute a valuable tool for the diagnosis of the Schistosoma sp. infection in special situations, when high sensitivity and specificity are required and infrastructure is available
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Esquistosomiasis
/
ADN Protozoario
/
Heces
Tipo de estudio:
Estudio diagnóstico
/
Factores de riesgo
Límite:
Animales
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2002
Tipo del documento:
Artículo
/
Congreso y conferencia
País de afiliación:
Brasil
Institución/País de afiliación:
Fiocruz/BR
/
Universidade de Säo Paulo/BR
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