Immunoglobulin E-rheumatoid factor in juvenile rheumatoid arthritis
Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo
;
57(5): 209-216, Sept.-Oct. 2002. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-325552
ABSTRACT
OBJECTIVES:
To determine the presence of immunoglobulin E-rheumatoid factor in patients with juvenile rheumatoid arthritis and to correlate it with clinical and laboratory parameters.METHODS:
A multicenter prospective study was carried out from January 1993 to January 1999 with the enrollment of 3 centers of pediatric rheumatology. Ninety-one children with juvenile rheumatoid arthritis diagnosed according to the American College of Rheumatology criteria were studied 38 (42 percent) with systemic, 28 (31 percent) with pauciarticular, and 25 (27 percent) with polyarticular onset. Ages ranged from 2.1 years to 22.6 years (mean 10.5 ± 4.7), with 59 (65 percent) girls. The control group consisted of 45 healthy children. The detection of immunoglobulin E-rheumatoid factor was carried out utilizing an enzyme-linked immunosorbent assay. Associations of immunoglobulin E-rheumatoid factor with immunoglobulin M-rheumatoid factor (latex agglutination test), total serum immunoglobulin E, erythrocyte sedimentation rate, antinuclear antibody, and functional and radiological classes III or IV were analyzed.RESULTS:
Positive immunoglobulin E-rheumatoid factor was found in 15 (16.5 percent) of the 91 children with juvenile rheumatoid arthritis 7 (18.5 percent) with systemic, 5 (18 percent) with pauciarticular, and 3 (12 percent) with polyarticular onset. A significant correlation was observed between immunoglobulin E-rheumatoid factor and total serum immunoglobulin E in the juvenile rheumatoid arthritis patients. No correlation was found between immunoglobulin E-rheumatoid factor and positive latex agglutination slide test, erythrocyte sedimentation rate, antinuclear antibody, or the functional and radiological classes III or IV in any disease onset group. In 4 out of 45 control children (8.9 percent), immunoglobulin E-rheumatoid factor was positive but with no correlation with total serum immunoglobulin E levels.CONCLUSIONS:
Immunoglobulin E-rheumatoid factor could be detected in 16.5 percent of juvenile rheumatoid arthritis patients, particularly in those with high levels of total serum immunoglobulin E, and immunoglobulin E-rheumatoid factor appears not to be associated with disease activity or severity
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Artritis Juvenil
/
Factor Reumatoide
/
Inmunoglobulina E
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio observacional
/
Factores de riesgo
Límite:
Adolescente
/
Adulto
/
Niño
/
Child, preschool
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo
Asunto de la revista:
Medicina
Año:
2002
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Federal University of Uberlândia/BR
/
University of Säo Paulo/BR
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