Low ethanol consumption increases insulin sensitivity in Wistar rats
Braz. j. med. biol. res
;
36(1): 125-130, Jan. 2003. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-326307
ABSTRACT
Several human studies suggest that light-to-moderate alcohol consumption is associated with enhanced insulin sensitivity, but these studies are not free of conflicting results. To determine if ethanol-enhanced insulin sensitivity could be demonstrated in an animal model, male Wistar rats were fed a standard chow diet and received drinking water without (control) or with different ethanol concentrations (0.5, 1.5, 3, 4.5 and 7 percent, v/v) for 4 weeks ad libitum. Then, an intravenous insulin tolerance test (IVITT) was performed to determine insulin sensitivity. Among the ethanol groups, only the 3 percent ethanol group showed an increase in insulin sensitivity based on the increase of the plasma glucose disappearance rate in the IVITT (30 percent, P<0.05). In addition, an intravenous glucose tolerance test (IVGTT) was performed in control and 3 percent ethanol animals. Insulin sensitivity was confirmed in 3 percent ethanol rats based on the reduction of insulin secretion in the IVGTT (35 percent, P<0.05), despite the same glucose profile. Additionally, the 3 percent ethanol treatment did not impair body weight gain or plasma aspartate aminotransferase and alanine aminotransferase activities. Thus, the present study established that 3 percent ethanol in the drinking water for 4 weeks in normal rats is a model of increased insulin sensitivity, which can be used for further investigations of the mechanisms involved
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Resistencia a la Insulina
/
Depresores del Sistema Nervioso Central
/
Etanol
Tipo de estudio:
Estudio diagnóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
2003
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade de São Paulo/BR
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