Vaccination of C57BL/10 mice against cutaneous leishmaniasis using killed promastigotes of different strains and species of Leishmania
Rev. Soc. Bras. Med. Trop
;
35(2): 125-132, Mar.-Apr. 2002. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-327475
ABSTRACT
Antigenic extracts from five Leishmania stocks were used to vaccinate C57BL/10 mice. The Leishvacin® and PH8 monovalent vaccine yielded the highest IFN-gamma levels in the supernatants of spleen cell culture from vaccinated animals. Each single strain immunized group showed evidence of protective immunity six months after the challenge with promastigotes of Leishmania (Leishmania) amazonensis. No differences were detected between the vaccinated groups. It can be concluded that vaccines composed of single Leishmania stocks can provide protection to C57BL/10 mice against L. (L.) amazonensis infection
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Vacunas Antiprotozoos
/
Vacunación
/
Leishmaniasis Cutánea
/
Leishmania
Límite:
Animales
Idioma:
Inglés
Revista:
Rev. Soc. Bras. Med. Trop
Asunto de la revista:
Medicina Tropical
Año:
2002
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Federal de Minas Gerais/BR
/
Universidade Federal de Ouro Preto/BR
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