Alteración de la respuesta inmunológica sistémica en asociación con endometriosis, empleando un modelo de estudio animal / Changes in the systemic immunologic response in association with endometriosis using an animal model
Ginecol. obstet. Méx
;
70(4): 171-181, abr. 2002.
Artículo
en Español
| LILACS
| ID: lil-331102
RESUMO
INTRODUCTION:
Endometriosis constitutes the growth of endometrial tissue in a place other than the uterine cavity. Its etiopathogenesis is unknown, although there is some evidence associating it with the decrease of cytotoxic activity in the immunological system.OBJECTIVE:
Evaluating the relationship between the development of ectopic endometrial tissue and the immunological status, and enumerating lymphocyte subpopulations and cytokine synthesis in T lymphocytes, using a murine endometriosis model.METHODOLOGY:
Spleen lymphocytes isolated from two study groups of 10 female mice of the Balb/c strain that had been submitted to the surgical implantation of autologous endometrial tissue in the peritoneal cavity, and sacrificed after 5 (group I) and 8 (group II) weeks, were incubated--or not--with PMA/lonomicine. Lymphocyte T numbers and their cytokine production were determined by flow cytometry.RESULTS:
A lower dispersion of the ectopic tissue growth value was observed in group II (24 vs. 42). A smaller population of cytotoxic T lymphocytes and a greater IL-4 production in the stimulated cells of the study group (p < 0.05) were observed, as compared to the control group.CONCLUSIONS:
The presence of endometrial tissue in the uterine cavity decreases the amount of cytotoxic T lymphocytes and increases IL-4 production in total T lymphocytes, suggesting a modulation of the systemic immunological response to TH-2.
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Índice:
LILACS (Américas)
Asunto principal:
Linfocitos T
/
Subgrupos de Linfocitos T
/
Interleucinas
/
Interferón gamma
/
Endometriosis
Tipo de estudio:
Estudio pronóstico
/
Factores de riesgo
Límite:
Animales
Idioma:
Español
Revista:
Ginecol. obstet. Méx
Asunto de la revista:
Ginecologia
/
Obstetrícia
Año:
2002
Tipo del documento:
Artículo
País de afiliación:
México
Institución/País de afiliación:
Instituto Nacional de Perinatología/MX
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