Estudo das alterações cardíacas em crianças com SIDA em relação à terapêutica com anti-retrovirais. Estudo prospectivo de 47 casos / Study of the cardiac alterations in HIV-infected children consequent to the antiretroviral therapy. Prospective study of 47 cases
Arq. bras. cardiol
;
80(3): 311-320, Mar. 2003. tab
Artículo
en Portugués, Inglés
| LILACS
| ID: lil-331109
ABSTRACT
OBJECTIVE:
Detect of cardiac alterations in children with AIDS and compare their evolution with the administration of only one anti-retroviral and the recent cases who received drugs in combination.METHODS:
We prospectively studied 47 children in 3 groups group 1, 20 cases treated only with zidovudine; group 2, 10 patients treated initially with zidovudine and later with a combination of drugs and in group 3, 17 patients, who receiced two or three since the beginning. In all patients it was done chest X-ray, EKG and echocardiography every 6 months and after death complete pathological study.RESULTS:
Among the 45 patients cases 26 (57 percent) were index cases. Malnutrition, diarrhea tachycardia, signs of congestive heart failure, pericardial effusion, abnormal ventricular repolarization and arrhythmias were more frequent in group 1. Echocardiographic abnormalities were present in 10 (50 percent) children of group 1. They were less frequent in the others two groups. In regard to the outcome in group 1, two patients had worsening of sings of cardiomyopaty and 4 died. Cardiac dysfunction in all cases of group 2 and 3 improved with the medication.CONCLUSION:
- The children who received combination and their cardiac alterations had more favorable outcome than those who received only one drug
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Zidovudina
/
Infecciones por VIH
/
Fármacos Anti-VIH
/
Corazón
/
Cardiopatías
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Límite:
Niño
/
Child, preschool
/
Humanos
/
Lactante
Idioma:
Inglés
/
Portugués
Revista:
Arq. bras. cardiol
Asunto de la revista:
Cardiología
Año:
2003
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Federal Fluminense/BR
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