Stress regulates the lymphocyte homing receptor CD62L (L-selectin)
Arq. neuropsiquiatr
;
61(1): 20-24, mar. 2003. graf
Artículo
en Inglés
| LILACS
| ID: lil-331153
RESUMO
Based on a previous study showing that panic disorder patients had increased expression of naïve phenotype lymphocytes (CD45RA+ and CD62L+), increased plasma cortisol, as well as decreased interleukin-2 (IL-2) producion, we hypothesized that changes in the percentage of expression of these lymphocyte surface molecules could be related to the substances released by the hypothalamic-pituitary-adrenal (HPA) axis and possibly associated to panic disorder (cortisol, IL-2, serotonin and epinephrine). In order to study the altered expression, blood mononuclear cells of normal volunteers were stimulated with mitogen, in the presence of dexamethasone, IL-2, serotonin and epinephrin. CD62L is decreased by IL-2 in vitro. Serotonin and epinephrine did not promote changes in the expression of these surface molecules. The results of the ex vivo study are in agreement with a previous clinical study with panic patients. It could be suggested that stress is responsible for certain immunologic dysfunctions and new studies should be conducted
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Estrés Psicológico
/
Técnicas In Vitro
/
Dexametasona
/
Linfocitos T
/
Epinefrina
/
Trastorno de Pánico
/
Selectina L
Tipo de estudio:
Estudio observacional
/
Factores de riesgo
Límite:
Humanos
Idioma:
Inglés
Revista:
Arq. neuropsiquiatr
Asunto de la revista:
Neurología
/
Psiquiatria
Año:
2003
Tipo del documento:
Artículo
País de afiliación:
Brasil
/
Estados Unidos
Institución/País de afiliación:
Harvard Medical School/US
/
Universidade Federal do Rio Grande do Sul/BR
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