Soroprevalência de anticorpos contra o antígeno CagA do Helicobacter pylori em pacientes com úlcera gástrica na regiÒo Norte do Brasil / Seroprevalence of antibodies against Helicobacter pylori CagA antigen in patients with gastric ulcer in the North region of Brazil
Rev. Soc. Bras. Med. Trop
;
35(4): 307-310, jul.-aug. 2002.
Artículo
en Portugués
| LILACS
| ID: lil-331752
ABSTRACT
Helicobacter pylori is a pathogenic agent with a worldwide distribution and is involved in the development of many gastrointestinal diseases. Nowadays infection with the virulent strain CagA+ of H. pylori is considered one of the main etiological factors in the development of gastric ulcer. Based on this information, we investigated the seroprevalence of virulent strains among patients with gastric ulcer from one region, using serologic tests to detect antibodies against H. pylori and CagA protein. Infection by the virulent strain was found in 82 (40/55) of the patients, and among these, 89 (40/45) presented an increased degree of inflammation in the gastric mucosa, with a dense infiltration of leukocytes in the tissue, which probably favored the formation of gastric ulcer. We concluded that the presence of the virulent strain is related to the development of an increased inflammation in the gastric mucosa.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Úlcera Gástrica
/
Proteínas Bacterianas
/
Helicobacter pylori
/
Anticuerpos Antibacterianos
/
Antígenos Bacterianos
Límite:
Adulto
/
Aged80
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Portugués
Revista:
Rev. Soc. Bras. Med. Trop
Asunto de la revista:
Medicina Tropical
Año:
2002
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Hospital Ofir Loiola/BR
/
Universidade Federal do Pará/BR
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