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Síndrome de Guillain-Barré: etiología y patogénesis / Guillain-Barre syndrome: etiology and pathogenesis
Avila-Funes, José Alberto; Mariona-Montero, Vitelio Augusto; Melano-Carranza, Efrén.
  • Avila-Funes, José Alberto; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. MX
  • Mariona-Montero, Vitelio Augusto; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. MX
  • Melano-Carranza, Efrén; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. MX
Rev. invest. clín ; 54(4): 357-363, jul.-ago. 2002.
Artículo en Español | LILACS | ID: lil-332902
ABSTRACT
Guillain-Barre syndrome (GBS) is a reactive, self-limited, monophasic disease triggered by a preceding bacterial or viral infection. GBS has also been linked to underlying systemic diseases, certain malignancies, surgery, pregnancy, trauma severe infection, and tissue transplantation (bone marrow and organs). Although its pathogenesis is unclear, it is likely to be a consequence of an immune mediated process. Therefore, we believe that GBS results from an aberrant immune response that somehow mistakenly attacks the nerve tissue of its host, most probably by recognizing a molecular similar epitope mechanism (molecular mimicry). Immune reactions against these epitopes result in acute inflammatory demyelinating neuropathy or acute axonal forms. GBS has a worldwide distribution with an annual incidence of approximately 1.2-8.6 cases per 100,000 people. Both genders are at similar risk (but there is a slight male predominance). All ages are affected, although the distribution is bimodal. The supporting measures are critically important to provide optimal treatment. Immunomodulation with plasma exchange and intravenous immunoglobulin treatments shorten the disease course. Outcome is generally good, with virtually full recovery in 70-80 of the patients. In this review physiopathological aspects and clinical implications of GBS are fully discussed.
Asunto(s)
Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Enfermedades Autoinmunes / Síndrome de Guillain-Barré Tipo de estudio: Estudio diagnóstico / Estudio de etiología / Estudio de incidencia / Estudio pronóstico Límite: Animales / Femenino / Humanos / Masculino Idioma: Español Revista: Rev. invest. clín Asunto de la revista: Medicina Año: 2002 Tipo del documento: Artículo País de afiliación: México Institución/País de afiliación: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán/MX

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Enfermedades Autoinmunes / Síndrome de Guillain-Barré Tipo de estudio: Estudio diagnóstico / Estudio de etiología / Estudio de incidencia / Estudio pronóstico Límite: Animales / Femenino / Humanos / Masculino Idioma: Español Revista: Rev. invest. clín Asunto de la revista: Medicina Año: 2002 Tipo del documento: Artículo País de afiliación: México Institución/País de afiliación: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán/MX