High prevalence of GB Virus C/Hepatitis G Virus RNA among Brazilian blood donors
Rev. Inst. Med. Trop. Säo Paulo
;
45(2): 75-78, Mar.-Apr. 2003. ilus, tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-333181
RESUMO
The aim of this study was to investigate the presence of the Hepatitis G Virus on a population of blood donors from São Paulo, Brazil and to evaluate its association to sociodemographic variables. Two RT-PCR systems targeting the putative 5'NCR and NS3 regions were employed and the former has shown a higher sensitivity. The observed prevalence of HGV-RNA on 545 blood donors was 9.7 percent (CI 95 percent 7.4;12.5). Statistical analysis depicted an association with race/ethnicity, black and mulatto donors being more frequently infected; and also with years of education, less educated donors presenting higher prevalences. No association was observed with other sociodemographic parameters as age, gender, place of birth and of residence. DNA sequencing of nine randomly chosen isolates demonstrated the presence of genotypes 1, 2 and 3 among our population but clustering of these Brazilian isolates was not detected upon phylogenetic analysis:
Texto completo:
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Índice:
LILACS (Américas)
Asunto principal:
Donantes de Sangre
/
Anticuerpos Antihepatitis
/
Infecciones por Flaviviridae
/
Virus GB-C
/
Hepatitis Viral Humana
Tipo de estudio:
Estudio diagnóstico
/
Estudio de prevalencia
/
Factores de riesgo
Límite:
Adolescente
/
Adulto
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Rev. Inst. Med. Trop. Säo Paulo
Asunto de la revista:
Medicina Tropical
Año:
2003
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Centro de Imunologia e Imunogenética/BR
/
Hospital Sírio-Libanês Blood Bank/BR
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