Anti-human immunodeficiency virus-1 antibody titers in injection drug users compared to sexually infected individuals
Mem. Inst. Oswaldo Cruz
;
98(2): 209-212, Mar. 15, 2003. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-334256
ABSTRACT
Sera from infected injection drug users (IDU) have shown to have antibodies against synthetic human immunodeficiency virus-1 (HIV-1) envelope peptides more frequently. In this study, reactivity of 48 IDU plasma were compared to 60 plasmas obtained from sexually infected individuals (S). The overall reactivity of plasma from IDU compared to S was higher, and the reactivity titers were much higher for IDU plasma than S. IDU plasma also showed a broader antibody response. The higher reactivity titers were observed mainly for the gp41 immunodominant epitope and V3 peptides corresponding to the consensus sequences of HIV-1 subtypes/variants prevalent in Brazil (B, F, C) indicating the specificity in the higher immune response of IDU
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Fragmentos de Péptidos
/
Anticuerpos Anti-VIH
/
Proteína gp41 de Envoltorio del VIH
/
Proteína gp120 de Envoltorio del VIH
/
Infecciones por VIH
/
VIH-1
Tipo de estudio:
Estudio pronóstico
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2003
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Fiocruz/BR
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