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Urticaria cronica. Evolucion clinica, prueba del suero autologo, recuento y activacion de basofilos / Chronic urticaria. Clinical evolution, autologous serum test, count and activation of basophils
Galassi, Nora; Riera, Norma; Rey, Graciela; Bracco, Maria Marta E; Malbran, Alejandro.
  • Galassi, Nora; Academia Nacional de Medicina. Instituto de Investigaciones Hematologicas. Buenos Aires. AR
  • Riera, Norma; Academia Nacional de Medicina. Instituto de Investigaciones Hematologicas. Buenos Aires. AR
  • Rey, Graciela; Unidad de Alergia e Inmunología.
  • Bracco, Maria Marta E; Academia Nacional de Medicina. Instituto de Investigaciones Hematologicas. Buenos Aires. AR
  • Malbran, Alejandro; Hospital Británico. Buenos Aires. AR
Medicina (B.Aires) ; 63(1): 15-20, 2003. graf
Artículo en Español | LILACS | ID: lil-334540
RESUMO
Recent advances on the pathogenesis of chronic urticaria have defined a group of patients with autoantibodies directed to the IgE or to the alpha chain of the Fc high affinity receptor of IgE, Fc epsilon RI alpha. These antibodies are detected in vivo through the autologous serum test (AST) and in vitro with a variety of techniques. We here describe 37 patients with chronic urticaria, 28 female and 9 male, with a f/m ratio of 3.1. Mean age at onset was 36.5 years (range 16-78). AST was positive in 25 (68%) of 37 patients. Serum induced a wheal significantly larger than plasma (122 +/- 78 mm2 vs 57 +/- 66 mm2, p < 0.05). Median persistence of the chronic urticaria, estimated by Kaplan-Meyer analysis, was 437 days, with no difference between AST(+) and AST(-) patients (437 vs. 369, p = 0.18). Mean IgE concentration was 157 +/- 173 IU/mL, as expected in an unselected population. Basophil count was lower in patients compared with controls (17 +/- 12 cel/microL vs. 43 +/- 27 cel/microL, p < 0.008). Only sera from 2/7 (28.6%) patients AST (+) and very low basophil count consistently induced expression of CD63. This effect was abrogated in non-releasing basophils, confirming the presence of antibodies directed to the Fc epsilon RI alpha-IgE. We conclude that functional antibodies are present in only a minority of patients and that their identification does not predict the

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Asunto(s)
Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Autoanticuerpos / Urticaria / Basófilos Tipo de estudio: Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Adolescente / Adulto / Femenino / Humanos / Masculino Idioma: Español Revista: Medicina (B.Aires) Asunto de la revista: Medicina Año: 2003 Tipo del documento: Artículo País de afiliación: Argentina Institución/País de afiliación: Academia Nacional de Medicina/AR / Hospital Británico/AR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Autoanticuerpos / Urticaria / Basófilos Tipo de estudio: Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Adolescente / Adulto / Femenino / Humanos / Masculino Idioma: Español Revista: Medicina (B.Aires) Asunto de la revista: Medicina Año: 2003 Tipo del documento: Artículo País de afiliación: Argentina Institución/País de afiliación: Academia Nacional de Medicina/AR / Hospital Británico/AR