A fibrose subendocárdica que acompanha o remodelamento ventricular do infarto do miocárdio está associada a redução da pressão de perfusão coronariana durante a fase aguda / Subendocardial fibrosis in remote myocardium results from reduction of coronary driving pressure during acute infarction in rats
Arq. bras. cardiol
;
80(5): 509-520, May 2003. ilus, tab, graf
Artículo
en Inglés, Portugués
| LILACS
| ID: lil-336448
RESUMO
OBJECTIVE:
To investigate the role of hemodynamic changes occurring during acute MI in subsequent fibrosis deposition within non-MI.METHODS:
By using the rat model of MI, 3 groups of 7 rats each [sham, SMI (MI <30 percent), and LMI (MI >30 percent)] were compared. Systemic and left ventricular (LV) hemodynamics were recorded 10 minutes before and after coronary artery ligature. Collagen volume fraction (CVF) was calculated in picrosirius red-stained heart tissue sections 4 weeks later.RESULTS:
Before surgery, all hemodynamic variables were comparable among groups. After surgery, LV end-diastolic pressure increased and coronary driving pressure decreased significantly in the LMI compared with the sham group. LV dP/dt max and dP/dt min of both the SMI and LMI groups were statistically different from those of the sham group. CVF within non-MI interventricular septum and right ventricle did not differ between each MI group and the sham group. Otherwise, subendocardial (SE) CVF was statistically greater in the LMI group. SE CVF correlated negatively with post-MI systemic blood pressure and coronary driving pressure, and positively with post-MI LV dP/dt min. Stepwise regression analysis identified post-MI coronary driving pressure as an independent predictor of SE CVF.CONCLUSION:
LV remodeling in rats with MI is characterized by predominant SE collagen deposition in non-MI and results from a reduction in myocardial perfusion pressure occurring early on in the setting of MI
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Presión Sanguínea
/
Fibrosis
/
Remodelación Ventricular
/
Endocardio
/
Ventrículos Cardíacos
/
Infarto del Miocardio
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
/
Portugués
Revista:
Arq. bras. cardiol
Asunto de la revista:
Cardiología
Año:
2003
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade de São Paulo/BR
Similares
MEDLINE
...
LILACS
LIS