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A fibrose subendocárdica que acompanha o remodelamento ventricular do infarto do miocárdio está associada a redução da pressão de perfusão coronariana durante a fase aguda / Subendocardial fibrosis in remote myocardium results from reduction of coronary driving pressure during acute infarction in rats
Frimm, Clovis de Carvalho; Koike, Marcia Kiyomi; Cúri, Mariana.
  • Frimm, Clovis de Carvalho; Universidade de São Paulo. Faculdade de Medicina. São Paulo. BR
  • Koike, Marcia Kiyomi; Universidade de São Paulo. São Paulo. BR
  • Cúri, Mariana; Universidade de São Paulo. São Paulo. BR
Arq. bras. cardiol ; 80(5): 509-520, May 2003. ilus, tab, graf
Artículo en Inglés, Portugués | LILACS | ID: lil-336448
RESUMO

OBJECTIVE:

To investigate the role of hemodynamic changes occurring during acute MI in subsequent fibrosis deposition within non-MI.

METHODS:

By using the rat model of MI, 3 groups of 7 rats each [sham, SMI (MI <30 percent), and LMI (MI >30 percent)] were compared. Systemic and left ventricular (LV) hemodynamics were recorded 10 minutes before and after coronary artery ligature. Collagen volume fraction (CVF) was calculated in picrosirius red-stained heart tissue sections 4 weeks later.

RESULTS:

Before surgery, all hemodynamic variables were comparable among groups. After surgery, LV end-diastolic pressure increased and coronary driving pressure decreased significantly in the LMI compared with the sham group. LV dP/dt max and dP/dt min of both the SMI and LMI groups were statistically different from those of the sham group. CVF within non-MI interventricular septum and right ventricle did not differ between each MI group and the sham group. Otherwise, subendocardial (SE) CVF was statistically greater in the LMI group. SE CVF correlated negatively with post-MI systemic blood pressure and coronary driving pressure, and positively with post-MI LV dP/dt min. Stepwise regression analysis identified post-MI coronary driving pressure as an independent predictor of SE CVF.

CONCLUSION:

LV remodeling in rats with MI is characterized by predominant SE collagen deposition in non-MI and results from a reduction in myocardial perfusion pressure occurring early on in the setting of MI
Asunto(s)
Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Presión Sanguínea / Fibrosis / Remodelación Ventricular / Endocardio / Ventrículos Cardíacos / Infarto del Miocardio Tipo de estudio: Estudio pronóstico Límite: Animales Idioma: Inglés / Portugués Revista: Arq. bras. cardiol Asunto de la revista: Cardiología Año: 2003 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade de São Paulo/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Presión Sanguínea / Fibrosis / Remodelación Ventricular / Endocardio / Ventrículos Cardíacos / Infarto del Miocardio Tipo de estudio: Estudio pronóstico Límite: Animales Idioma: Inglés / Portugués Revista: Arq. bras. cardiol Asunto de la revista: Cardiología Año: 2003 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade de São Paulo/BR