Apoptosis y cáncer / Apoptosis and Cancer

RESUMO

Apoptosis is a basic biological phenomenon with wide-ranging implications in tissue kinetics. This article describes several concepts related to apoptosis regulators and their role in tumor genesis, with special reference to its significance in cancer and in cancer therapy. Molecular aspects of cell death and disease and cytometry in cell necrobiology with analysis of accidental cell death are considered. Mitochondria as the central control pint of apoptosis, considering definition, mechanisms and relevance, are referred. The implications of basic research for clinical oncology are considered, describing recent concepts of mechanism and significance: