Factors associated with penicillin-nonsusceptible pneumococcal infections in Brazil
Braz. j. med. biol. res
; 36(6): 807-813, June 2003. tab
Article
en En
| LILACS
| ID: lil-340658
Biblioteca responsable:
BR1.1
ABSTRACT
Resistance of Streptococcus pneumoniae is a worldwide, growing problem. Studies of factors associated with resistance to penicillin have not been conducted in Brazil. The objective of the present study was to evaluate factors associated with infection by S. pneumoniae not susceptible to penicillin. A prevalence study was conducted including all patients with a positive culture for S. pneumoniae in a hospital from July 1991 to December 1992 and the year 1994. Of 165 patients identified, 139 were considered to have clinically relevant infections and 88 percent of them had invasive infections. All infections were community acquired and consisted of pneumonia (44 percent) and of central nervous system (19 percent), pelvic or abdominal (12 percent), upper airway or ocular (12 percent), primary bloodstream (9 percent) and skin and soft tissue (5 percent) infections. Mortality was 25 percent. Susceptibility to penicillin was present in 77.6 percent of the isolates; 21.8 percent were relatively resistant, and one isolate was resistant (minimal inhibitory concentration = 4 æg/ml). Multivariate analysis showed that age below 4 years (odds ratio (OR) 3.53, 95 percent confidence interval (95 percentCI) 1.39-8.96) and renal failure (OR 5.50, 95 percentCI 1.07-28.36) were associated with lack of susceptibility to penicillin. Bacteremia occurred significantly less frequently in penicillin-nonsusceptible infections (OR 0.34, 95 percentCI 0.14-0.84), possibly suggesting that lack of penicillin susceptibility is associated with lower virulence in S. pneumoniae
Texto completo:
1
Índice:
LILACS
Asunto principal:
Infecciones Neumocócicas
/
Streptococcus pneumoniae
/
Resistencia a las Penicilinas
Tipo de estudio:
Etiology_studies
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Prevalence_studies
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Prognostic_studies
Límite:
Adult
/
Child
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Child, preschool
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Female
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Humans
/
Male
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Braz. j. med. biol. res
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
2003
Tipo del documento:
Article