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Association studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery disease
Simon, D; Paludo, C. A; Ghisleni, G. C; Manfroi, W. C; Roisenberg, I.
  • Simon, D; Universidade Federal do Rio Grande do Sul. Faculdade de Medicina. Instituto de Biociências. Departamento de Genética. Porto Alegre. BR
  • Paludo, C. A; Universidade Federal do Rio Grande do Sul. Faculdade de Medicina. Instituto de Biociências. Departamento de Genética. Porto Alegre. BR
  • Ghisleni, G. C; Universidade Federal do Rio Grande do Sul. Faculdade de Medicina. Instituto de Biociências. Departamento de Genética. Porto Alegre. BR
  • Manfroi, W. C; Universidade Federal do Rio Grande do Sul. Faculdade de Medicina. Hospital de Clínicas de Porto Alegre. Serviço de Cardiologia. Porto Alegre. BR
  • Roisenberg, I; Universidade Federal do Rio Grande do Sul. Faculdade de Medicina. Instituto de Biociências. Departamento de Genética. Porto Alegre. BR
Braz. j. med. biol. res ; 36(6): 709-714, June 2003. tab
Artículo en Inglés | LILACS | ID: lil-340663
ABSTRACT
High levels of von Willebrand factor (vWF) have been associated with cardiovascular disease. The A allele of the -1185A/G polymorphism in the 5'-regulatory region of the vWF gene was associated with the highest plasma vWF levels in a normal population. To examine the association between -1185A/G polymorphism and coronary artery disease (CAD), 173 Brazilian Caucasian subjects submitted to coronary angiography were studied. Of these, 57 (33 percent) had normal coronary arteries (control group) and 116 (67 percent) had CAD (patient group). Plasma vWF levels were higher in patients (145 U/dl) than in controls (130 U/dl), but the differences were significant only for O blood group subjects. Polymerase chain reaction amplification of the 864-bp vWF promoter region followed by AccII restriction digestion was used to identify the -1185A/G genotypes. The -1185A allele frequency was 43.1 percent in patients and 44.7 percent in controls. Allele and genotype frequencies were not significantly different between patients and controls. No association was observed between the -1185A/G genotypes and plasma vWF levels in patients or controls. These results suggest that -1185A/G polymorphism is not an independent risk factor for CAD
Asunto(s)
Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Factor de von Willebrand / Enfermedad Coronaria Tipo de estudio: Estudio de etiología / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Adulto / Aged80 / Femenino / Humanos / Masculino Idioma: Inglés Revista: Braz. j. med. biol. res Asunto de la revista: Biologia / Medicina Año: 2003 Tipo del documento: Artículo / Documento de proyecto País de afiliación: Brasil Institución/País de afiliación: Universidade Federal do Rio Grande do Sul/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Factor de von Willebrand / Enfermedad Coronaria Tipo de estudio: Estudio de etiología / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Adulto / Aged80 / Femenino / Humanos / Masculino Idioma: Inglés Revista: Braz. j. med. biol. res Asunto de la revista: Biologia / Medicina Año: 2003 Tipo del documento: Artículo / Documento de proyecto País de afiliación: Brasil Institución/País de afiliación: Universidade Federal do Rio Grande do Sul/BR