Antiphospholipid antibodies in 57 children and adolescents with systemic lupus erythematosus
Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo
;
58(3): 157-162, 2003. tab
Artículo
en Inglés
| LILACS
| ID: lil-342135
ABSTRACT
OBJECTIVE:
To investigate the frequencies and behavior of antiphospholipid antibodies in 57 children and adolescents with systemic lupus erythematosus.METHODS:
Anticardiolipin antibodies were investigated by ELISA and lupus anticoagulant antibodies by the international tests recommended. The antiphospholipid antibodies analyses were performed in frozen samples (mean of 5.3 samples per patient obtained during a mean follow-up period of 3 years and 7 months) and on blood samples collected between January 1997 and November 1998 (mean of 2.5 samples per patient during a 2-year follow-up period).RESULTS:
The frequencies of antiphospholipid antibodies (anticardiolipin and lupus anticoagulant) were similar in the samples collected prospectively and in the frozen samples (retrospective study) 63.2 percent and 75.4 percent respectively. Positivity for these antibodies fluctuated during the follow-up period and was not associated with any clinical or laboratory parameters of lupus erythematosus, including autoantibodies and also including disease activity and/or severity scores.CONCLUSIONS:
The frequencies of antiphospholipid antibodies in children and adolescents with lupus erythematosus were similar to those observed in adults. The positivity fluctuated during the follow-up and was not correlated with clinical and/or laboratory disease parameters
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Síndrome Antifosfolípido
/
Anticuerpos Antifosfolípidos
/
Lupus Eritematoso Sistémico
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adolescente
/
Adulto
/
Niño
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo
Asunto de la revista:
Medicina
Año:
2003
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
University of Säo Paulo/BR
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