Toxoplasmose em coelhos: comparação do perfil bioquímico hepático com os achados patológicos em infecção pelo toxoplasma gondii / Toxoplasmosis in rabbits: profile hepatic biochemistry and its relationship with pathological found due to toxoplasma gondii

RESUMO

To determine the hepatic profiles due to Toxoplasma gondii infection in rabbits, 15 animals were divided in three groups of five animals each. The first and second groups were inoculated subcutaneously with 106 and 103 tachyzoites of T. gondii respectively, while the third was left as control. Blood samples were taken on days 0, 4, 8, e 11 after inoculation (DAI). Livers of each rabbit was analyzed in other to observed lesions. Hepathomegaly was observed in all of the infected groups, independently of the dose used, where was observed a significant increase of AST e ALT at 8th DAI. Tachyzoites were observed in all infected animals, and were reisolated in 90 percent of livers bioassed in mice. Histopathology was consisted by diffuse infiltration inflammatory, consisted mainly by lymphocytes at sinusoids e portal space. The increase of AST and ALT during acute toxoplasmosis in rabbits was justified by presence of tachyzoites in tissue smears associated with gross and histopathologic lesions