Resistencia insulínica y otras expresiones del síndrome metabólico en niños obesos chilenos / Insulin resistance in obese Chilean children
Rev. méd. Chile
;
131(3): 259-268, mar. 2003. tab, graf
Artículo
en Español
| LILACS
| ID: lil-342312
RESUMO
Background:
Infantile obesity is a probable risk factor for the early appearance of chronic illnesses like Type 2 Diabetes Mellitus, Dislipidemia and Hypertension. Insulin Resistance (IR) appears as the common etiological mechanism.Aim:
To describe metabolic complications associated to obesity in a group of Chilean children and to correlate them with IR, estimated through the homeostasis model assessment index (HOMA). Subjects andmethods:
We studied 88 children, 12ñ2.4 years old. Fifty two had severe obesity, 19 were overweight, and 17 had a normal weight (body mass index z score (BMIz) 4.7ñ1.6, 1.7ñ0.5 and 0.2ñ0.6 respectively, p <0.001). In obese children, an oral glucose tolerance test, measuring basal and 30 min insulin levels, was performed and serum lipid levels were measured.Results:
Eleven percent of the severely obese children were glucose intolerant, 67 percent had basal hyperinsulinemia (>20 uU/ml) and 79 percent had IR (HOMA >3.8). These children also had a higher prevalence of acantosis nigricans than the overweight and normal counterparts (63, 10.5 and 0 percent respectively, p <0.001), higher basal insulinemia (24.4ñ10, 16.4ñ4 and 12.2ñ3 mU/ml respectively) and HOMA (5.3ñ2, 3.4ñ0.8 and 2.3ñ0.5 respectively, p <0.001). By multiple stepwise regression analysis, BMIz was the only significant predictor for basal hyperinsulinemia, HOMA and diastolic blood pressure. Age and BMIz were independent predictors for systolic blood pressure. The strongest predictor for plasma lipid levels was the family history of dislipidemia.Conclusions:
Obese children have a high prevalence of metabolic complications, which are related to the severity of obesity. Most of the severely obese children have hyperinsulinism and IR. BMIz is the principal predictor for high blood pressure. Familiar history is the better predictor for dislipidemia
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Resistencia a la Insulina
/
Obesidad
Tipo de estudio:
Estudio de etiología
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adolescente
/
Niño
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Chile
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2003
Tipo del documento:
Artículo
País de afiliación:
Chile
Institución/País de afiliación:
Pontificia Universidad Católica de Chile/CL
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