A randomized controlled trial comparing split and subunit influenza vaccines in adults in Colombia
Medicina (B.Aires)
;
63(3): 197-204, 2003. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-343166
ABSTRACT
In a two-center, comparative trial, 344 adults were randomly assigned to receive a single dose of inactivated split-virion (Imovax Gripe) or sub-unit (Agripal S1) influenza vaccine (1999-2000 formulations). For analysis, study groups were subdivided into adult (18-60 years old) and elderly (over 60 years) subjects. Blood was drawn immediately before and one month after vaccination, safety was evaluated using a blind-observer design based on reporting of solicited and unsolicited adverse events. Both vaccines were very well torelated, had similar reactogenicity profiles, and elicited fewer reports of reactions in elderly individuals. Post-vaccination Imovax Gripe induced seroprotective antibody titers against the three vaccine strains in 94-99% of adults and 88-97% od elderly subjects, compared with 88-100% and 88-98%, respectively, of those given Agrippal S1. In conclusion, the split-virion and sub-unit influenza had similar safety and reactogenicity profiles, and elicited satisfactory immunuty in adult and elderly subjects. However, higher post-vaccination geometric mean titer (GMT) values in response to the B strain were seen with the split vaccine Imovax Gripe, giving it a better overall immunogenicity.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Vacunas contra la Influenza
/
Gripe Humana
Tipo de estudio:
Ensayo Clínico Controlado
Límite:
Adolescente
/
Adulto
/
Aged80
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Colombia
Idioma:
Inglés
Revista:
Medicina (B.Aires)
Asunto de la revista:
Medicina
Año:
2003
Tipo del documento:
Artículo
País de afiliación:
Colombia
/
Francia
Institución/País de afiliación:
Aventis Pasteur International/FR
/
Siplas LTDA/CO
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