Antibacterial xanthones from Kielmeyera variabilis mart. (Clusiaceae)
Mem. Inst. Oswaldo Cruz
;
98(4): 549-552, June 2003. ilus, tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-344253
ABSTRACT
The bioassay-guided fractionation of stems from Kielmeyera variabilis, traditionally used in Brazilian folk medicine, yielded assiguxanthone-B (1), kielcorin (4), 2,5-dihydroxybenzoic acid (3), and a mixture of xanthones containing assiguxanthone-B (1) and 1,3,5,6-tetrahydroxy-2-prenylxanthone (2) (11 w/w). The xanthone mixture inhibited Staphylococcus aureus and Bacillus subtilis at a concentration of 6.25 µg/ml. When tested alone, the minimal inhibitory concentration of assiguxanthone-B was 25 µg/ml against B. subtilis. Kielcorin and 2,5-dihydroxybenzoic acid were inactive against both strains. None of the fractions was active against Escherichia coli or Pseudomonas aeruginosa. Viable cells of S. aureus were reduced by a 1-3 log CFU/ml within 12 h after exposure of one to eight times the MIC of the xanthone mixture. It is not known whether the tetrahydroxy-2-prenylxanthone or other components of the xanthone mixture are responsible for the main antibacterial activity or whether additive or synergistic action is involved
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Xantenos
/
Ericales
/
Bacterias Gramnegativas
/
Bacterias Grampositivas
/
Antiinfecciosos
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2003
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Instituto de Botânica de São Paulo/BR
/
Universidade Estadual de Maringá/BR
/
Universidade Federal de São Carlos/BR
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