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Sputum induction: review of literature and proposal for a protocol
Scheicher, Marcos Eduardo; Terra Filho, Joäo; Vianna, Elcio Oliveira.
  • Scheicher, Marcos Eduardo; Universidade de Säo Paulo, Ribeiräo Preto. Faculdade de Medicina de Ribeiräo Preto. Department of Medicine. Pulmonary Division. Ribeiräo Preto. BR
  • Terra Filho, Joäo; Universidade de Säo Paulo, Ribeiräo Preto. Faculdade de Medicina de Ribeiräo Preto. Department of Medicine. Pulmonary Division. Ribeiräo Preto. BR
  • Vianna, Elcio Oliveira; Universidade de Säo Paulo, Ribeiräo Preto. Faculdade de Medicina de Ribeiräo Preto. Department of Medicine. Pulmonary Division. Ribeiräo Preto. BR
São Paulo med. j ; 121(5): 213-219, Sept. 1, 2003. ilus, tab
Artículo en Inglés | LILACS | ID: lil-349456
RESUMO
Since the 1980s, sputum induction by inhalation of hypertonic saline has been successfully used for diagnosing Pneumocystis carinii pneumonia in patients infected with HIV. In recent years, sputum induction and its subsequent processing has been refined as a noninvasive research tool providing important information about inflammatory events in the lower airways, and it has been used for studying various illnesses. In asthma, one application is to use sputum inflammatory indices to increase our understanding of complex relationships between inflammatory cells, mediators, and cytokine mechanisms. In chronic obstructive pulmonary disease, sputum assessment could be used as a screening test before deciding on long-term corticosteroid treatment. In tuberculosis, sputum induction is a valuable diagnostic tool for HIV-seropositive patients who do not produce sputum. Sputum induction appears to be a relatively safe, noninvasive means of obtaining airway secretions from subjectswith cystic fibrosis, especially from those who do not normally produce sputum. Moreover, sputum induction can also be used in chronic cough and lung cancer. Generally, induction is performed through ultrasonic nebulizers, using hypertonic saline. It is recommended that sputum be processed as soon as possible, with complete homogenization by the use of dithiothreitol. We have also shown in this article an example of a protocol for inducing and processing sputum employing a nebulizer produced in Brazil
Asunto(s)
Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Solución Salina Hipertónica / Esputo / Nebulizadores y Vaporizadores / Enfermedades Pulmonares Tipo de estudio: Guía de Práctica Clínica Límite: Humanos Idioma: Inglés Revista: São Paulo med. j Asunto de la revista: Cirurgia Geral / Ciˆncia / Ginecologia / Medicina / Medicina Interna / Obstetr¡cia / Pediatria / Sa£de Mental / Sa£de P£blica Año: 2003 Tipo del documento: Artículo / Documento de proyecto País de afiliación: Brasil Institución/País de afiliación: Universidade de Säo Paulo, Ribeiräo Preto/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Solución Salina Hipertónica / Esputo / Nebulizadores y Vaporizadores / Enfermedades Pulmonares Tipo de estudio: Guía de Práctica Clínica Límite: Humanos Idioma: Inglés Revista: São Paulo med. j Asunto de la revista: Cirurgia Geral / Ciˆncia / Ginecologia / Medicina / Medicina Interna / Obstetr¡cia / Pediatria / Sa£de Mental / Sa£de P£blica Año: 2003 Tipo del documento: Artículo / Documento de proyecto País de afiliación: Brasil Institución/País de afiliación: Universidade de Säo Paulo, Ribeiräo Preto/BR