Doxorubicin and etoposide induce somatic recombination in diploid cells of Aspergillus nidulans
Braz. j. microbiol
;
33(3): 255-259, July-Sept. 2002. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-349779
ABSTRACT
Doxorubicin and etoposide are intercalating agents that inhibit the action of the enzyme topoisomerase II. Both drugs present therapeutic activity in numerous human neoplasms In the present work the recombinagenic potential of these drugs was evaluated by ascomycete Aspergillus nidulans. Their effects on the asexual cycle of A. nidulans was also appraised. Two heterozygous diploid strains of A. nidulans, a wild (uvsH+//uvsH+) and a defective to the DNA repair (uvsH//uvsH) were used. The drugs' recombinagenic potential was evaluated by their capacity to induce homozygosis of recessive genes from heterozygous cells. Both drugs have a recombinagenic effect on diploid cells of A. nidulans. Doxorubicin and etoposide are potentially capable to induce secondary malignancies, mediated by the mitotic crossing-over in eukaryotic cells
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Aspergillus nidulans
/
Recombinación Genética
/
Técnicas In Vitro
/
Doxorrubicina
/
Fármacos actuantes sobre Aminoácidos Excitadores
/
Pruebas Enzimáticas Clínicas
/
Etopósido
Tipo de estudio:
Estudios de evaluación
Idioma:
Inglés
Revista:
Braz. j. microbiol
Asunto de la revista:
Microbiologia
Año:
2002
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Estadual de Maringá/BR
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